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肿瘤坏死因子α基因多态性与非酒精性脂肪性肝病胰岛素抵抗的相关性 被引量:6

Association between tumor necrosis factor-alpha gene polymorphism and insulin resistance in nonalcoholic fatty liver disease
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摘要 胰岛素抵抗(IR)目前被认为是非酒精性脂肪性肝病(NAFLD)的主要发病机制。研究表明肿瘤坏死因子(TNF)α及其基因多态性与IR关系密切。我们通过检测NAFLD患者的TNFα基因多态性及其血浆水平,探讨了TNFα与IR之间的相关性。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第8期613-615,共3页 Chinese Journal of Hepatology
基金 广州市医疗机构重点专科科研基金
关键词 肿瘤坏死因子 脂肪肝 胰岛素 Tumor necrosis factor Fatty liver Insulin
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参考文献13

  • 1Diehl AM. Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clin Liver Dis, 2004, 8: 619-638.
  • 2Valenti L, Fracanzani AL, Dongiovanni E et al. Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology, 2002, 122:274-280.
  • 3中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊断标准[J].中华肝脏病杂志,2003,11(2):71-71. 被引量:1366
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二级参考文献3

  • 1Wigg AT, Roberts IC, Dymock RB, et al. The role of small intestimal bacterial overgrowth and tumor necrosis factor-α in the pathogenesis of nonalcoholic steatohepatitis [J ]. Gut,2001,48 (2):206.
  • 2Mcweegan E. TNF antibodies get new lease[J]. Nature Med,1997,3(1): 130.
  • 3肖文斌,贾万金,刘玉兰.非酒精性脂肪性肝炎研究进展[J].临床肝胆病杂志,2001,17(2):71-73. 被引量:54

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