摘要
目的观察黄芪醇提物对吗啡诱导的小鼠条件性位置偏爱(CPP)效应的影响。方法吗啡6mg/kg连续给药适应训练6 d,建立小鼠吗啡CPP模型,观察黄芪醇提物对CPP的影响。结果吗啡可诱导小鼠对伴药箱产生显著的CPP;训练阶段于每次给予吗啡前30 min给予黄芪醇提物200,400和800 mg/kg可拮抗小鼠对吗啡的CPP效应(与吗啡对照组比较P<0.05,P<0.01,P<0.01);测试前30 min一次给予黄芪醇提物800mg/kg可抑制小鼠已形成的CPP(P<0.01),但黄芪醇提物200和400 mg/kg不影响其效应(P>0.05);且黄芪醇提物自身不会使小鼠产生CPP。结论黄芪醇提物能在一定程度上抑制吗啡诱导的小鼠CPP效应的形成和表达,其自身无潜在精神依赖性。
Objective To investigate the effect of Astragalus membranaceus alcohol extracts on morphine-induced conditioned place preference（CPP） in mice. Methods Mice were trained for 6 days by sc morphine（6 mg/kg） once a day to establish a morphine CPP model and observed the effect of A. membranaceus alcohol extracts on the model. Results Morphine induced mice to obtain a significant CPP. When mice were pretreated 30 min before each injection of morphine during the training phase with A. membranaceus alcohol extracts（200, 400 and 800 mg/kg）. The CPP induced by morphine was antagonized remarkably（P〈0.05, P〈0.01, P〈0.01）. When A. membranaceus alcohol extracts 800 mg/kg was administered only once 30 min before the testing, the CPP induced by morphine was inhibited, but with 200 or 400 mg/kg, no effect was shown. A. membranaceus alcohol extracts itself did not induce CPP in mice. Conclusion A. membranaceus alcohol extracts could restrain the acquisition and expression of morphine-induced CPP in mice to a certain extent, and has no potential of psychological dependence.
出处
《福建医科大学学报》
2006年第4期353-356,共4页
Journal of Fujian Medical University
基金
福建省自然科学基金资助项目(C0410026)
福建医科大学科学研究发展基金资助项目(01601024)
关键词
黄芪
吗啡依赖
疾病模型
动物
小鼠
Astragalus membranaceus
morphine dependence
disease models,animal
mice
