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神经生长因子与阿尔茨海默病的关系

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作者 谢玉华 张静 陈晓春
机构地区 福建医科大学附属协和医院老年研究所
出处 《福建医科大学学报》 2006年第4期412-415,共4页 Journal of Fujian Medical University
基金 福建省自然科学基金资助项目(C0510019)
关键词 神经生长因子 阿尔茨海默病 受体 胆碱能 神经元
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献32

  • 1Young M,Blanchard MH,Sessions F, et al. Subunit structure of high molecular weight mouse nerve growth factor[J]. Biochemistry, 1988,27(18):6675-6681.
  • 2Bax B,Blundell TL,J Murray-Rust, et al. Structure of mouse 7S NGF:a complex of nerve growth factor with four binding proteins[J]. Structure, 1997,5(10):1275-1285.
  • 3Robertson AG,Banfield MJ,Allen SJ, et al. Identification and structure of the nerve growth factor binding site on TrkA[J]. Biochem Biophys Res Commun, 2001,282(1):131-141.
  • 4VanDer ZC,Hagg T. Delayed NGF infusion fails to reverse axotomyinduced degeneration of basal forebrain cholinergic neurons in adult p75(LNTR)-deficient mice[J]. Neuroscience, 2002,110(4):641-651.
  • 5Nichols A,Martinou I,Maundrell K, et al. The p75 neurotrophin receptor: effects on neuron survival in vitro and interaction with death domain-containing adaptor proteins[J]. Apoptosis, 1998,3(4):289-294.
  • 6Kume T,Nishikawa H,Tomioka H, et al. p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures[J]. Brain Res, 2000,852(2):279-289.
  • 7Xing J,Kornhauser JM,Xia ZG, et al. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogenactivated protein kinase pathways to stimulate CREB serine 133 phosphorylation[J]. Mol Cell Biol, 1998,18(4):1946-1955.
  • 8Nusser N,Elvira G,Zheng Y, et al. Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells[J]. J Biol Chem, 2002,277(39):35840-35846.
  • 9Bonnington JK,McNaughton PA. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor[J]. J Physiol, 2003,551(2):433-446.
  • 10Lee TH，Kato H,Pan LH, et al. Localization of nerve growth factor,trkA and P75 immunoreactivity in the hippocampal formation and basal forebrain of adult rats[J]. Neuroscience, 1998,83(2):335-349.

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共引文献38

福建医科大学学报
2006年 第4期

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