姜黄素衍生物FM02的溶解度、抗抑郁和抗炎作用

The Anti-Depression Effect and the Anti-Inflammation Effect of Curcumin Derivative FM02

目的测定姜黄素衍生物FM02的溶解度及药理作用。方法分别用水、二甲亚砜(DMSO)、甲醇溶解FM02,测定溶解度;用强迫小鼠游泳实验测定抗抑郁作用;用巴豆油引起小鼠耳肿胀模型测定抗炎作用;用MTT法测定对K562细胞增殖作用的影响。结果FM02易溶于水、甲醇及DMSO,溶解度均>0.1 g/g;剂量5mg/kg与10 mg/kg灌胃对小鼠强迫游泳模型有明显的抗抑郁作用,5 mg/kg相对抗抑郁强度为46.8%;一次性给药对巴豆油引起小鼠耳肿胀模型有一定的抑制作用,但与阴性对照组比较,差异不显著;对K562细胞无抑制作用。结论FM02具有较好的水溶性,剂量5 mg/kg与10 mg/kg小鼠灌胃具有较好的抗抑郁作用。

Objective To determinate the solubility and pharmacological activity of curcumin derivative FM02. Methods Solubility assay of FM02 was tested with water, dimethyl sulfoxide（DMSO）, and carbinol. Anti-depression effect of FM02 was determined with forced swimming method. Anti-inflammatory effect of FM02 was tested with croton oil induced mouse ear edema model. To determine the inhibition effect of the proliferation of K562 cell was detrmined. Results FM02 was water soluble. The solubility in carbinol or DMSO was less than 0.1 g/g. The anti-depression effect of FM02 was significant at dosage of 5 mg/kg and 10 mg/kg ig and achieved 46.8% tensity. FM02 showed some anti-inflammatory effect. FM02 didn＇t inhibit the growth of cell line K562. Conclusion FM02 is water soluble. The anti-depression effect of FM02 is significant at dosage of 5 mg/kg and 10 mg/kg ig.