腺苷对营养性大鼠肥胖及肠系膜微循环的影响

The Effects of Adenosine on Rats' Mesentery Microcirculation and Nutritional Obese

目的:探讨腺苷对营养性大鼠肥胖及肠系膜微循环的影响。方法:大鼠分为普通饲料喂养组(A组),高能饲料喂养肥胖模型组(B组),CPA+高能饲料喂养模型组(C组)。检测大鼠体重、小肠肠系膜微循环的血管口径、流速和流态,计算Lee’s指数。结果:⑴B组大鼠体重增长率大于A组(P<0.01),C组大鼠体重增加小于B组(P<0.01),但明显高于A组(P<0.05);⑵B组Lee’s指数大于A组(P<0.05),而C组小于B组(P<0.05);(3)大鼠小肠肠系膜微循环变化:B组微血管口径大于A组(P<0.05),C组微血管口径明显小于B组(P<0.05),A组和C组血流速度均快于B组(P<0.01)。结论:腺苷可干预大鼠肥胖发生,可能与腺苷改善微循环有关。

Objective: To investigate the effects of adenosine(CPA) on mesentery microcirculation and nutritional obese of rats.Method: The rats were randomly divided into three group. Group A was given normal food,and group B was given high energy food, and group C was given CPA + high energy food.The changes of body weight and mesenteric microcirculation were observed respectively;Meanwhile,Lee's index was measured.Results: (1)The average body weight increasing rate in group B was higher than that of group A(P<0.01),the average body weight increasing rate of C group was less than that of group B(P<0.01),but it was significantly higher than that of group A(P<0.05).(2) Lee’s index of group B was higher than that of group A (P<0.05),the Lee’s index of group C was less than that of group B( P<0.05).(3) The changes of mesenteric microcirculation in rats: The vascular diameter of mesenteric microcirculation in group A was significantly less than that of group B ( P<0.05);compared to group B,group C was significantly decreased in the same index ( P<0.05).The blood flowing speed in group A and group C were faster than that of group B(P<0.01).Conclusion: Statistical data indicated that CPA can interfere with the obese of rats,which might be concerned with obviously improve mesenteric microcirculation in obese rats.