血脂与血液流变性的关系及其对高血压的影响

The Relationship Between Blood lipid and Hemorheology and Their Effect on Hypertension

高血压病是常见病、多发病，病因及机制十分复杂，目前认为是在各种因素的影响下，致使血压的调节功能失调所致。最近的研究报道，高血压病存在血液流变性和脂质代谢的异常。但是高血压病患者血脂与血液流变性指标之间的相关性，目前国内外尚未见研究报导。本研究对482例高血压患者和100例健康人分别进行胆固醇（Cho-C）、甘油三酯（TG）、低密度脂蛋白（LDL—C）、高密度脂蛋白（HDL—C）、载脂蛋白A（apoA）、载脂蛋白B（apoB）以及血液流变性等指标的测定，以探讨血脂与血液流变性的关系及其对高血压患者血压的影响。

Objective: To explore the relationship between blood lipid and hemorheology and their effect on hypertension. Method: SBP, DBP, Cho-C, TG, apoA, apoB, LDL-C, HDL-C and hemorheological indexes were measured in 482 cases with hypertension, then compared them with those of 100 healthy subjects.Results: The Hypertension group was positively correlated with blood viscosity of low shear rate(ηbL),erythrocyte sedimentation rate ESR, Equation K value of ESR, the time of erythrocyte electrophoresis(P<0.05~0.01). TG was positively correlated with ηbL,blood viscosity of middle shear rate(ηbM),ESR, Equation K value of ESR, SBP and DBP. Blood viscosity,erythrocyte aggregation index EAI and the time of Erythrocyte Electrophoresis were positively correlated with DBP (P<0.05). ηbM,ηbL were positively correlated with SBP(P<0.01). Conclusion: hyperlipemia and high blood viscosity have close relation with hypertension. Blood lipid and blood viscosity interact with hypertension and are the cause and effect of each other,thus vicious circle is produced.