摘要
胶质细胞源性神经营养因子（ＧＤＮＦ）是１９９３年发现并克隆的神经营养因子，对巴金森氏病（Ｐａｒｋｉｎｓｏｎ’ｓｄｉｓｅａｓｅ）和运动神经元性疾病等的治疗可能具有潜在的应用价值。本文对其蛋白质的性质、基因结构、分布以及其在生理、病理情况下的作用进行了简要的综述。
Glia cell line-derived neurotrophic factor(GDNF) is a novel type of neurotrophic factor cloned in 1993. Recent research revealed that it may have potential application in the treatment of Parkinson’s disease and motor neuron diseases. This short review summarized the character of the protein, gene structure,tissue distribution , and its physiological functions and pathological implications.
出处
《生理科学进展》
CAS
CSCD
北大核心
1996年第4期301-306,共6页
Progress in Physiological Sciences
基金
国家自然科学基金
香港北美医学基金
关键词
胶质细胞源性
神经营养因子
病理
生理
Glia cell line-derived neurotrophic factor
Dopaminergic neuron
Cholinergic Neuron
Parkinson’s disease
Motor neuron disease
