慢性房颤患者TXB_2、6-K-PGF_(1α)和PGE_2的变化探讨

Study on the Changes of Serum Levels of TXB_2,6-K-PGF_(1α) and PGE_2 in Patients with Chronic Atrial Fibrillation

目的:研究慢性心房纤颤(CAF)患者血清血栓素B2(TXB2)、6-酮-前列腺素F1α(6-K-PGF1α)和前列腺素E2(PGE2)水平的变化及其临床意义。方法:放射免疫分析测定162例CAF患者、60例无CAF患者和40例对照组的血清TXB2、6-K-PGF1α和PGE2水平,并进行统计分析。结果:CAF组血清TXB2水平显著高于无CAF组和对照组(P均<0.01),6-K-PGF1α显著低于对照组(P<0.01),PGE2三组间无显著差异(P均>0.05),CAF组中TXB2与6-K-PGF1α成显著正相关(P<0.01)。CAF患者中Ⅰ、Ⅱ、Ⅲ、Ⅳ级心功能组间平均血清TXB2和6-K-PGF1α水平均呈依次显著性递增(P均<0.01),PGE2无显著性改变(P>0.05);伴脑血栓组血清TXB2和6-K-PGF1α水平均显著高于无脑血栓组(P均<0.01);住院死亡组血清TXB2水平显著高于好转出院组(P<0.01)。结论:CAF患者血清TXB2水平显著增高,并随心功能分级依次递增,伴脑血栓组更高,死亡组TXB2也明显增高;CAF患者血清6-K-PGF1α水平明显降低;PGE2则无明显改变。

Objective To study clinical significance of the changes of serum thromboxane B2（TXB2）, 6 - keto - PGF1α（6 - K -PGF1α） and prostaglandin E2 （PGE2 ） levels in patients with chronic atrial fibrillation （CAF）. Methods Serum TXBz, 6 -K- PGF1α and PGE2 levels in 162 CAF patients, 60 non - CAF cardiac patients, and 40 controls were determined with radioimmunoassay. Results The serum TXB2 level in CAF patients was significantly higher than that in non - CAF patients （ P 〈 0.01 ） and CON cases （P 〈0.01 ）, serum 6 - K - PGF1α level was significantly lower than that in CON cases （P 〈0.01 ）, but no difference in serum PGE2 （ P 〉 0.05 ）. The serum TXBz levels was positively significantly correlated with the serum 6 - K - PGF1α levels （ P 〈 0.01 ） in CAF patients. The serum TXB2 and 6 - K - PGF1α levels increase by degrees in different step CAF patients （ NYHA. Ⅰ、Ⅱ、Ⅲ、Ⅳ ） （P 〈0. 01 ）. In patients with brain - embolism （ BE）, the serum TXB2 and 6 - K - PGF1α were significantly higher than that in non - BE pa- tients. And in died patients, the TXB2 was significantly highter than in no - died patients （ P 〈 0.01 ）. Conclusion In CAF pa- tients, the TXB2 was increased, but the 6 -K-PGF1α was decreased, and more in heart failure patients. In BE patients, the TXB2 and 6 - K - PGF1α were increased. In died patients the TXB2 was increased.