妊高征患者血清TNF-α和外周血B细胞及T淋巴细胞亚群水平检测的临床意义

Clinical Significance of Determination of Changes of Serum TNF-α Levels,Peripheral B Lymphocyte Count and T Lymphocyte Subsets Distribution Pattern in Patients with Pregnancy Induced Hypertension Syndrome

目的:探讨妊高征患者血清TNF-α和外周血B和T淋巴细胞亚群水平及临床意义。方法:分别应用放免法和单克隆抗体法对34例妊高征患者进行了血清TNF-α和外周血B及T淋巴细胞亚群水平检测,并与35名正常健康人作比较。结果:妊高征患者血清TNF-α、B细胞数量均显著高于正常对照组(P<0.01),而CD3、CD4、CD4/CD8比值则显著低于正常对照组(P<0.01)。结论:妊高征是一种和自身免疫调节异常相关的疾病。

Objective To explore the changes of serum TNF-α levels, peripheral B cell count and T subsets distribution pattern in patients with pregnancy induced hypertension syndrome. Methods Serum TNF-α levels （with RIA）, peripheral B cell count as well as T subsets （with monoclonal technique） were examined in 34 patients with pregnancy induced hypertension syndrome and 35 controls. Results The serum TNF-α levels and B lymphocytes count were significantly higher than those in controls （ P 〈 0. 01 ）, while the CD3, CD4, CD4/CD8 ratio were significantly lower than those in controls （ P 〈 0.01 ）. Conclusion Pregnancy induced hypertension syndrome is a kind of autoimmune diseases with abnormal immunoregulation.