摘要
从海洋生物胚胎细胞到哺乳动物的细胞周期,主要是在其细胞周期基因产物周期素及p34(cdc2)的调控下启动、运行和脱出周期的;某些原癌基因或抑癌基因的产物如p53、pRB也直接调控着细胞周期。但是,促进细胞有丝分裂的p34(cdc2)也能够启动某些类型细胞的凋亡。因此,细胞周期正常调控成分的突变,将使细胞凋亡,或使细胞增殖失控。
The progression of cell cycle in embryonic cells from oceanic bionts to mammalians is initiated, promoted and terminated under the regulation of cell cycle gene products,named cyclins,and a p34 (cdc 2 ). Besides, oncogene(proto-oncogene)products such as p53 and pRB also directly regulate the progression of cell cycle, Howeverf the p34(cdc 2)which promotes the mitotic cell division also initiates the apoptosis of certain cells.Therefore, mutations of genes that regulate the normal progression of cell cycle would cause cells in the cell cycle undergoing either apoptosis or uncontrollable proliferation.
出处
《生理科学进展》
CAS
CSCD
北大核心
1996年第4期319-323,共5页
Progress in Physiological Sciences
基金
GrowthFactor公司资助
关键词
细胞周期
细胞
细胞凋亡
Cell cycle
Apoptosis
Programmed cell death
Cylin
Death gene