肾上腺皮质激素在应激性高血压发病中的中枢机制

The Central Mechanism of Corticoids in the Incidence of Stress-Induced Hypertension

本工作观察到应激性高血压大鼠发病过程中伴随着出现血浆儿茶酚胺、皮质酮以及血糖、血脂的平行升高。肾上腺皮质激素微量注射至延髓头端腹外侧区（ｒＶＬＭ）可引起升压、加快心率及增强防御性升压反应，该作用可能是应激性高血压发病机制的重要环节之一，其机制可能通过对该区心血管神经元的快速膜效应而实现，并与该区胆碱能系统活动的异常增强和钙通道的激活有关。而ｒＶＬＭ的ＮＯ系统对该区心血管神经元具有抑制性作用。

We observed that in rats during the incidence of hypertension induced by stress,an increase in the plasma concentrations of catecholamines, corticosterone,glucose and lipids is parallel with an elevation of blood pressure and heart rate. Microinjection of corticoids into the rVLM elicits an effect of pressor,tachycardia and enhancement of pressor response to stimulation of the defense area, this may be one of the important causes in the incidence of stress-induced hypertension. Ths effect is taken place by a rapid membrane effect of the corticoids on the cardiovaseular neurons in the rVLM, which is related to an abnormal enhancement of cholinergic activity and activation of calcium channel.Whereas NO plays an inhibitory effect on the cardiovascular neurons in the rVLM.