脊髓背角痛觉传递和调制的一些化学解剖学观察

Chemical Anatomy of the Nociceptive Transmission and Modulation in the Spinal Dorsal Horn

本实验研究了脊髓背角内Ｃ纤维末梢的分布和突触学特征及其一些神经递质化学构筑；定量观察了急性痛引起背角的递质变化；显示了初级传入Ｃ纤维、抑制性中间神经元和背角伤害性感受神经元三者之间的突触关系，并探讨它们在痛觉信息传递和调制中的作用。结果表明急性痛刺激可引起Ｃ类末梢共释放Ｐ物质和谷氨酸，通过其受体或兴奋脊髓背角上行投射神经元或直接激活背角内γ－氨基丁酸能镇痛系统。

The present study had been made to study the distribution and synaptic characteristics of primary afferent C fibers and the normal chemical architecture of some neurotransmitters in spinal dorsal horn,The changes of the neurotransmitters with acute nociceptive stimulation were measured quantitatively.We demonstrated the synaptic relationships among primthry afferent C fibers, inhibitory interneurons and nociceptive dorsal horn neurons and discussed their function in nociceptive transmission and modulation. These results provide evidence that acute pain evolved co-release of substance P and glutamate from C-fiber terminals may constitute a driving force for secondary activation of ascending projection neurons or of internal GABAergic antinoceciptive system directly via their receptors in the dorsal horn of the spinal cord.