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心肌细胞L型钙通道研究进展 被引量:3

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摘要 心肌细胞膜上存在两种不同类型电压依赖性钙通道,其中L型钙通道具有重要的生理意义,与某些心血管疾病的发生及治疗密切相关,研究也最为深入。本文就近年来有关心肌L型钙通道分子生物学结构、门控特征、动力学模型、调节机制等方面的研究进展作一综述。
出处 《生理科学进展》 CAS CSCD 北大核心 1996年第4期362-364,共3页 Progress in Physiological Sciences
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  • 1黄淑君,田苗,廖玉华.柯萨奇病毒B3感染培养大鼠心室肌细胞L-型钙通道mRNA表达的变化[J].中国分子心脏病学杂志,2003,3(3):159-163. 被引量:1
  • 2Yatani A,Shen Y T,Yan L,et al.Down regulation of the L-type Ca2+ channel,GRK2,and phosphorylated phospholamban:protective mechanisms for the denervated failing heart.[J].Mol Cell Cardiol,2006,40(5):619-628.
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  • 6Mark E A.Calmodulin Kinase and L-Type calcium channels:a recipe for arrhythmias[J].Trends Cardiovas Med,2004,14(4):152-161.
  • 7Ding Y F,Brower G L,Zhong Q,et al.Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats[J].Clin Exp Pharmacol Physiol,2008,35(7):827-835.
  • 8Yamamoto T,Yano M.Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts[J].Circulation,2008,117(3):762-768.
  • 9Xu M,Zhou P,Wang S Q.Intermolecular failure of L-type Ca2+channel and ryanodine receptor signaling in hypertrophy[J].PloS Biol,2007,5(2):575-582.
  • 10Izu L T,Means S A,Balke C W.Interplay of ryanodine receptor distribution and calcium dynamics[J].Biophysics,2006,91(1):95-112.

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