乳腺癌中survivin的表达及其与抑癌基因PTEN的相关性

Expression of Survivin and its correlation with PTEN in breast cancer

目的探讨survivin在乳腺癌组织中的表达情况及其与抑癌基因PTEN和PCNA的关系。方法用免疫组化方法(S-P法)对60例乳腺癌和18例乳腺增生症的石蜡包埋标本进行Survivin、PTEN、PCNA的检测,其中PCNA指数作为衡量乳腺癌细胞增殖活性的参数。结合病人的临床病理资料进行χ2检验和t检验。结果Survivin在乳腺癌中的阳性表达率明显高于乳腺小叶增生(P<0.05);Survivin的表达与PCNA密切相关;survivin和PTEN在乳腺癌中的表达呈负相关。结论Survivin的表达在良、恶性乳腺肿瘤间有显著差别,survivin的表达与乳腺癌细胞增殖活性显著相关,这表明survivin的异常表达是乳腺癌发生、发展相关因素。PTEN和survivin在乳腺癌中的表达呈负相关,两者共同参与了乳腺癌发生和发展。

[Objectives] To study the expression of Survivin and its correlation with PTEN and PCNA in breast cancer. [Methods] The expression of Survivin, PTEN and PCNA was detected in 60 cases paraffin embedded of breast cancer and 18 cases of hyperplasia of mammary gland by immunohistochemical technique（SP）, index （LI） of PCNA was acted as a marker of the cellular proliferating activity. Chnnicopathologic elements were analyzed by chi square test（x^2） and t-test. [Results] The positive rate of Survivin in breast cancer is higher than that in hyperplasia of mammary gland （P 〈0.05）, and the expression of Survivin was positively correlated with PCNA in breast cancer. There was a negative correlation between the expression of PTEN and survivin in breast cancer. [Conclusion] The difference between malignant and benign breast carcinoma was significant, the expression Survivin is correlated with the cellular proliferating activity in breast cancer, and it is probably that the abnormal expression of Survivin promote oncogennesis and pogression in breast cancer; the expression of Survivin is inversely correlated with PTEN, they may have the synergism in the carcinogenesis and progress of breast cancer.