帕罗西汀治疗伴情绪障碍的偏头痛

Paroxetine in treatment of migraine with emotional disorder

目的：探讨帕罗西汀治疗伴有情绪障碍的偏头痛的临床疗效。方法：将偏头痛病人127例分为2组,帕罗西汀组68例[男性26例,女性42例,年龄(30±s 12)a,13～74 a],口服帕罗西汀20 mg,每早1次,1 wk后加至40 mg,每早1次,头痛缓解1wk后给予维持量10mg,每早1次；硫必利组59例[男性24例,女性35例,年龄(30±18)a,15～68 a],入院后即给予硫必利100mg,每日3次,维持量为50 mg,每日2～3次,均6wk为一个疗程。进行对照研究,用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)对其抑郁焦虑状态进行治疗前及治疗后(wk 2,4,6)评估。结果：帕罗西汀组和硫必利组不仅可以明显减轻病人的抑郁焦虑症状,还可以显著减轻偏头痛发作次数,缩短头痛发作的时间(P＜0．01)；帕罗西汀组总有效率96%(65/68),硫必利组总有效率81%(48/59),2组疗效比较,经Ridit分析有显著差异(P＜0．05)。结论：帕罗西汀治疗伴有情绪障碍的偏头痛有较好疗效。

AIM： To study the clinic efficacy of paroxetine in curing migraine with emotional disorder METHODS： One hundred and twenty-seven patients were divided into 2 groups. The paroxetine group （n = 68, M 26, F 42; age （30±s 12） a, 13-74 a） were treated with paroxetine 20 mg, po, qd, then added to 40 mg, po, qd, one week later and then until one week after relief of headache reducing dose to 10 mg, po, qd as for maintenance. The tiapride group （n = 59, M 24, F 35; age （30±18） a, 15-68 a） were treated with tiapride 100 mg, po, tid, and with maintaining dose of 50 mg, po, bid or tid. The whole course all covered for 6 wk. The depression and anxiety status were evaluated with HAMD depression capacity table and HAMA anxiety capacity table. RESULTS： Paroxetine could not only decrease the depression and anxiety symptoms in patients obviously but also reduce the attack times of headache and shorten the attack time of headache remarkably in paroxetine group （P 〈 0.05, P 〈 0.01） . The efficacy rate of paroxetine group reached 96 % （65/68）, and that of tiapride group was 81% （48/59）, with P〈 0.05 by Ridit analysis. CONCLUSION： Paroxetine possesses better efficacy in curing migraine.