烟酸调脂治疗临床应用现状和进展

Present status and development of niacin in regulation of dyslipidemia clinically

烟酸具有降低血浆总胆固醇、三酰甘油、低密度脂蛋白胆固醇和脂蛋白(a),升高高密度脂蛋白胆固醇的作用,但是普通制剂有众多的不良反应大大限制了它的使用。随着烟酸缓释剂型的问世,其不良反应明显降低,为临床调脂治疗和联合用药提供了一种更安全、有效的选择。

Niacin is a commonly used antidyslipidemic agent that effectively decreases the plasma levels of total cholesterol, triglycerides （TG）, LDL cholesterol （LDL-C）, and LP （a）, and increases HDL cholesterol （HDL-C）, but the use of niacin has been largely restricted by adverse effects （eg, flushing and hepatic toxicity）. The emergence of the extended-release niacin （niacin-ER） formulation afford a better choice with more effectiveness and less adverse reactions for hyperlipidemia as well as its combined treatment.