合成苏氨酸的研究（V）─DL－别苏氨酸的光学拆分

Studies on Synthesis of Threonine (V)──Optical Resolution of DL-allo-Threonine

研究了用优先结晶法对ＤＬ－别苏氨酸进行光学活性拆分的问题，在相图基础上选取适当的过饱和度，即配制成原始拆分母液。作为晶种，既可用光活性别苏氨酸，也可用光活性苏氨酸，可用对映的一对光活性晶种，还介绍用单一晶种的拆分方法，提出了Ｌ－别苏氨酸与Ｌ－苏氨酸、Ｄ－别苏氨酸与Ｄ－苏氨酸为“胶着对”，Ｌ－别苏氨酸与Ｄ－苏氨酸，Ｌ－别苏氨酸与Ｄ－苏氨酸为“离散对”的观点。

Optical resolution of DL-allo-Threonine have been investigated by perferential crystalloization at roomtemperature,oversaturated degree of 0.02-0.05g DL-allo-Thr/g-H_2O is selected. Not only optical allo-Threonine,but also optical active Threonine can be used as crystal seed. Two methods of resolution using single optical seed have been demonstrated.