新型可降解钙磷骨水泥多孔支架研究

Novel Biodegradable Scaffold of Calcium Phosphate Cement

采用一种特殊的方法制备了孔径、孔隙率和孔形状可控的多孔羟基磷灰石骨水泥支架．材料的抗压强度可达4MPa,孔隙率可达70％,孔与孔之间互相贯通,大孔壁富含微孔．细胞在材料表面黏附铺展且增殖良好,体外模拟实验显示材料的降解速度随孔隙率的增加和Ca／P比的降低而加快,多孔支架有优良的生物降解性和生物相容性．该材料可用于修复骨组织缺损和作为支架材料用于组织工程．

A novel porous scaffold of calcium phosphate cement with porosity-controllable pore size-controllable and morphology-controllable was prepared and cell culture with scaffold was studied, also, the biodegradation of the porous scaffold in SBF was investigated. The results reveal that the compressive strength of the porous bone cement can reach 4MPa, the porosity of the scaffold can reach 70%, abundant micropores are on the wall of the macroposes and the pores are interconnected with each other, the cultural cell are attached, dispersed and preferentially proliferated on the surface of the scaffolds materials. The biodegradation ratio increases with the increasing of porosity and decreasing of Ca/P ratio of the calcium phosphate cement. The scaffolds not only have good biocompatibility but also biodegradation. The novel new type of biodegradable Ca-P materials can be used as scaffolds for bone defect repair and tissue engineering.