Study on the Relationship between P-glycoprotein and CD44 Expression in Gastric Carcinoma

客观：在 P-glycoprotein (P-gp ) 和象他们在胃的癌的临床的意义一样的粘附分子 CD44 之间的关系的调查。方法：Toexamine 在有由流动 cytometryand 的胃的癌的 98 种情况中的 P-gp 和 CD44 的表示水平与 clinicopathological 因素评估他们的关系。结果：在 98 胃的癌之中， 40 个盒子(40.8%) 是 P-gp negative (积极房间 【 25%) ；P-gp 积极房间的 14 盒子(14.2%)were25%-40% 表示；17 个盒子(17.3%) 是 P-gp 积极房间的 41%-60% 表示；27 个盒子(27.5%) 是高表示(积极房间 】 60%) 在有胃的癌的所有病人的 P-gp。当肿瘤尺寸是超过 6 厘米时， CD44 积极的 P-gp 显示出有效差量(P 【 0.05 ) 在有 P-gp 的 35 种情况中积极，与它相比在 24 情况 withP-gp negative。当肿瘤在低中等的区分的胃的癌时， CD44 的表示显示出有效差量(P 【 0.05 ) 在有 P-gp 的 44 种情况中积极，作为与它相比在有 P-gp 的 30 种情况中否定。当病人在临床的Ⅲ - Ⅳ舞台时， CD44 的表示显示出有效差量(P 【 0.05 ) 在有 P-gp 的 42 种情况中积极，作为与它相比在有 P-gp 的 30 种情况中否定。什么时候有淋巴节点转移的病人， theirCD44 表示显示出有效差量(P 【 0.05 ) 在有 P-gp 的 46 种情况中积极，与它相比在有 P-gp 的 32 种情况中否定。肿瘤 P-gp 什么时候表示了积极，他们的 CD44expression 将是增加。结论：当 CD44 和 P-gp 两个都有积极高表示时，它将显著地与胃的癌前进和转移被联系因此两个是在胃的癌的积极表情，它可能建议差、相反的预后结果。

Objective： Investigation of the relationship between P-glycoprotein （P-gp） and adhesion molecule CD44 as well as their clinical significance in gastric carcinoma. Methods： To examine the expressed level of P-gp and CD44 in 98 cases with gastric carcinoma by flow eytometry and evaluate their relationships with elinieopathologieal factors. Results： Among the 98 gastric carcinomas, 40 cases （40.8%） were P-gp negative （positive cells 〈25%）; 14 cases （14.2%） were 25%-40% expression of P-gp positive cells; 17 cases （17.3%） were 41%-60% expression of P-gp positive cells; 27 cases （27.5%） were the high expression （positive cells 〉60%） of P-gp in all patients with gastric carcinoma. When the tumor sizes were more than 6 cm, the P-gp positive of CD44 showed a significant difference （P〈0.05） in 35 cases with P-gp positive, compared with it in 24 cases with P-gp negative. When the tumors were in low-moderate differentiated gastric carcinoma, the expression of CD44 showed a significant difference （P〈0.05） in 44 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients were in clinical Ⅲ-Ⅳ stage, the expression of CD44 showed a significant difference （P〈0.05） in 42 cases with P-gp positive, as compared with it in 30 cases with P-gp negative. When the patients with lymph node metastasis, their CD44 expression showed a significant difference （P〈0.05） in 46 cases with P-gp positive, compared with it in 32 cases with P-gp negative. When the tumors P-gp expressed positive, their CD44 expression will be increase. Conclusion： When the CD44 and P-gp both have the positive high expression, it will be significantly associated with the gastric carcinoma progression and metastasis, so both were a positive expression in gastric carcinoma, it might suggest a poor and unfavorable prognosis result.