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三羟异黄酮对大鼠肠缺血再灌注损伤的保护作用 被引量:1

Protective effects of genistein on intestinal ischemia-reperfusion injury in rats
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摘要 目的:研究三羟异黄酮对肠缺血再灌注损伤的影响。方法:24只雄性Wistar大鼠随机分为假手术组(S组)、肠缺血再灌注损伤组(IIRI组)和三羟异黄酮组(G组)。观察三组肠组织病理学变化,测定比较肠组织湿/干重比(W/D)、髓过氧化物酶(MPO)活性、细胞因子诱导的中性粒细胞趋化因子-1(CINC-1)含量和血浆D-乳酸含量。结果:与S组比较,IIRI组肠损伤严重,W/D、MPO活性、CINC-1含量和血浆D-乳酸含量升高(P<0.01);与IIRI组比较,G组肠损伤明显减轻,W/D、MPO活性、CINC-1含量和血浆D-乳酸含量降低(P<0.05或P<0.01)。结论:三羟异黄酮对肠缺血再灌注损伤具有保护作用,可能与其下调CINC-1的表达而抑制中性粒细胞在肠组织的聚集有关。 Objective:To investigate the effects of genistein on intestinal ischemia-reperfusion injury in rats. Methods:Twenty-four Wistar rats were randomly assigned to one of three groups: sham operation group (S group), intestinal ischemia-reperfusion injury group (IIRI group) and genistein group (G group). Wet-to-dry weight (W/D) ratio, myeloperoxidase (MPO) activity, cytokine-induced neutrophil chemoattractant-1 (CINC-1) content in intestinal tissues and plasma D-lactate level were measured. The histopathological changes in intestines were also assayed. Results:W/D, MPO activity, CINC- 1 content in intestinal tissues and plasma D-lactate level were significantly higher in IIRI group than that in S group (P〈0.01). The values in these indexes were significantly lower in G group than that in IIRI group (P〈0.05 or P〈0.01). Ischemia-reperfusion also induced extensive histepathological intestine injury, which was reduced by genistein pretreatment. Conclusion:Pretreatment with genistein has protective effect on intestinal ischemia-reperfusion injury in rats, which may involve in an inhibition of neutrophilic recruitment possibly through an inhibition of CINC-1 expression.
出处 《温州医学院学报》 CAS 2006年第4期326-327,共2页 Journal of Wenzhou Medical College
关键词 三羟异黄酮 缺血再灌注 小肠 髓过氧化物酶 细胞因子诱导的中性粒细胞趋化因子-1 genistein Ischemia-reperfusion small intestine myeloperoxidase cytokine-induced neutrophil chemoattractant-1
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