醛固酮与肺心病患者肺动脉高压的关系

Relationship of phathogenesis between aldosterone and pulmonary hypertension in chronic pulmonary heart disease

目的:研究血浆醛固酮浓度对肺动脉高压的影响。方法:110例慢性阻塞性肺病患者分为肺心病组与慢阻肺组,比较两组之间及与对照组间的血浆醛固酮浓度;分析血浆醛固酮浓度与肺动脉压力的关系。结果:肺心病组血浆醛固酮浓度为(101.53±117.44)ng/L,显著高于慢阻肺组的(54.14±36.90)ng/L及健康组的(60.38±43.13)ng/L;血浆醛固酮浓度与肺动脉压力的相关性分析显示血浆醛固酮浓度与肺动脉高压的呈线性正相关关系(r=0.05,P<0.05);logistic回归分析显示血浆醛固酮浓度与肺动脉高压正相关(r=1.355,P<0.05)。结论:醛固酮增多是肺动脉高压的危险因素。

Objective：To investigate the relationship between the Plasma aldosteron levels and pulmonary hypertension. Methods：1） 110 cases COPD patients were divided into two groups according to whether or not with chronic cot pulmonale. They were called COPD group and chronic cot pulmonale group. Plasma aldosteron levels were monitored in 110 cases COPD patients and healthy individuals. 2） Regression was analyzed between plasma aldosteron levels and pulmonary tension. 3） logistic Regression was analyzed between plasma aldosteron levels and pulmonary hypertension. Results： 1）The result showed that the level of plasma aldosteronwas significantly higher in chronic cot pulmonale groups than that in two other groups （P〈0.05）. 2） Linear correlation showed plasma aldosteron levels was positively correlated with pulmonary hypertension （r=0.05, P〈0.05）. 3） Logistic Regression showed plasma aldosteron levels was positively correlated with pulmonary hypertension （r=1.355, P〈0.05）. Conclusion：Plasma aldosteron is one of the harmful factors in pulmonary hypertension.