硝苯吡啶联合交沙霉素治疗毛细支气管炎的疗效观察

Clinical Effects of Nifedipine Combined with Josamycin Treating the Bronchiolitis

目的观察硝苯吡啶联合交沙霉素治疗毛细支气管炎的临床效果。方法将112例患儿随机分为两组,均常规给以抗感染、吸氧、镇静治疗,有心功能衰竭者给以西地兰或毒毛旋花子素K、利尿剂等综合治疗。治疗组患儿在常规治疗的基础上每日加用硝苯吡啶1mg/kg、交沙霉素30mg/kg,分3次口服。结果治疗组显效46例,有效12例,无效4例;对照组显效10例,有效34例,无效6例,两组患儿疗效间差别有显著性意义(P<0·001);两组患儿憋喘缓解时间及肺部罗音消失时间的分布间差别均有显著性意义(P<0·001)。结论硝苯吡啶联合交沙霉素治疗毛细支气管炎疗效较好,能有效缩短憋喘和肺部罗音持续的时间。

Objective To observe the clinical effects of nifedipine combined with josamycin treating the bronchiolitis. Methods 112 children were divided into two groups randomly, anti - infection, oxygen - inhalation and sedation were ordered for both groups. Patients with heart failure were given cedilanid or strophanthin K and diuretic. Patients in the treatment group took nifedipine 1 mg · kg^-1· d^- 1, Josamycin 30 mg · kg^-1· d^- 1, three times daily by mouth. Results In the treatment group, 46 cases had obvious effect, 12 had efficiency, 4 had no effects. The total effective rate was 95.55%. And in control group, 10 cases had obvious effect, 34 had efficiency, 6 cases had no effects. The total effective rate was 88%. There were significant difference in the time of breathlessness relief and rales disappearing between the treatment group and control group （ P 〈 0. 001 ）. Conclusion Nifedipine combined josamycin in the treatment of bronchitis has a better effect, which is worthy using widely in pediatric wards.