小剂量米非司酮用于子宫内膜异位症手术后的疗效观察

Mifepristone following conservative surgery in the treatment of endometriosis

目的 探讨保留生育功能或保留卵巢功能手术后服用小剂量米非司酮治疗子宫内膜异位症（内异症）的临床疗效、副反应。方法 米非司酮组20例，予米非司酮10mg口服，每日1次；达那唑组27例，予达那唑200mg口服，每日2～3次，均连续用药6个月。观察2组症状、体征改善情况及用药后的副反应。结果 2组症状、体征缓解率相似。米非司酮组潮热、阴道出血、腰背疼痛、体重增加、痤疮等副反应发生率显著低于达那唑组（P〈0．05）。结论 手术后加用米非司酮可明显改善患者症状和体征，疗效与达那唑类似，但副反应明显减少。

Objective To compare the efficacy and safety of Mifepristone and Danazol after conservative surgery in the treatment of patients with endometriosis. Methods Fourty-seven patients with endometriosis （ rAPS stage Ⅰ-Ⅳ） after conservative surgery were treated orally either with Mifepristone 10 mg/d （ group M, n = 20 ） or Danazol200 mg 2 - 3 times/d （ group D, n = 27 ） for 6 months. Changs of symptoms and signs as well as side effects were assessed before and at the end of therapy. Results During treatment symptoms and signs were remarkably relieved in beth groups. Side effects including hot flushes, irregular vaginal bleeding,backpain, weight gain and acne,were less commonly seen in group M as compared with Group D. Conclusions Mifepristone is equally effective to Danazol when combined with conservative surgery in the management of endometriosis with fewer side effects.