摘要
目的:比较鸡骨草(JGC)、毛鸡骨草(MJGC)对小鼠急性肝损伤的保护作用。方法:用CCl4造成急性肝损伤和用卡介苗(BCG)与脂多糖(LPS)诱导的小鼠免疫性肝损伤模型,观察JGC和MJGC对血清中谷丙转氨酶(ALT)及谷草转氨酶(AST)活性的影响。结果:JGC和MJGC对CCl4肝损伤小鼠AST和ALT有明显降低作用,P<0.01或0.05;对BCG和LPS诱导的小鼠免疫性肝损伤JGC(60g/kg)和MJGC(60、40g/kg)AST有降低的作用,P<0.01或0.05。结论:JGC和MJGC对CCl4肝损伤和BCG与LPS诱导的小鼠免疫性肝损伤均有一定的保护作用,但两者的作用无明显差异。
Objective: To compare the protective effect of herba abri (JGC) and semi-finished herba abri (MJGC) on acute liver lesion rats. Methods: The mode of acute liver lesion rats was caused by the use of CCl_4, BCG and LPS to observe the effects of JGC and MJGC on the activity of ALT and AST in the blood serum. Results: The ALT and AST of JGC and MJGC showed an obvious lowering effect on the CCl_4 liver lesion rats, P<0.01 or P<0.05. The AST of JGC (60 kg) and MJGC (60 kg, 40 kg) showed an obvious lowering effect on the BCG and LPS liver lesion rats, P<0.01 or P<0.05. Conclusion: JGC and MJGC have a certain protective effect on the liver lesion rats caused by CCl_4, BCG and LPS, but the two materials have no obvious difference.
出处
《云南中医中药杂志》
2006年第4期35-36,共2页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
关键词
鸡骨草
毛鸡骨草
护肝实验
herba abri
semi-finished herba abri
liver-protection
