摘要
根据４种贝母抑制由ＰＡＦ诱导血小板聚集部位筛选结果，从平贝母的水溶性活性部位中分得胸苷和腺苷等成分。试验表明腺苷为抑制聚集的主要成分。提示核苷类可能是贝母中除生物碱外的另一类活性成分。
Based on platelet aggregation induced by platelet activating factor(PAF) .the active fraction with in-hibiting effect was sereened from four spacies of Chinese drung Beimu.the bulbs of Fritillaria przewalskii, F. us-suriensis. F. anhuiensis and F. thunbergii.According to the experimental results. the active water soluble fraction ofF. ussuriensis was further studied. Two nucleosides, thymidine and adenosine were isolated. Platelet aggregation as-say shows that adenosine is the chief aggregation inhibitor with 1%= 42 at 5μm. It is suggestad that nucleosides maybe the other type of active constituent besides alkaloids in the Fritiaria plants.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1996年第7期420-422,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金
关键词
中药
贝母属
平贝母
腺苷
胸苷
成分分析
genus Fritillaria
F. ussuriensis
adenosine
thymidine
platelet aggregation assay
