摘要
扶正化瘀319方治疗慢性乙型肝炎56例,并以大黄虫丸治疗的19例患者为对照,临床有效率分别为87.5%和68.4%。该方不但能有效地改善肝功能及临床症状,且能降低患者显著增高的血清单胺氧化酶B(MAO-B)活性,金属蛋白酶组织抑制因子-1(TIMP)、Ⅲ型前胶原肽、Ⅳ型胶原、透明质酸及层粘蛋白(LN)的含量,提高尿羟脯氨酸(Hyp)排泄量(P<0.001~0.05)。与对照组相比,除TIMP外.改善程度均以观察组为著。表明该方对慢性乙型肝炎具有较好的治疗效果,在一定程度上抑制了肝纤维化的进展。
Fifty-six patients with chronic hepatitis B were treated with Fuzheng Huayu 319 Recipe (319 Recipe) for supplementing body resistance and removing blood stasis, the efficacy was compared with that of 19 cases treated with Dahuang Zhechong Pill as control. The effective rate of the two groups were 87.5o/o and 68.4o/o respectively. Results showed that the 319 Recipe could not only improve the clinical symptoms and liver functions, but also reduce the serum levels of monoamine oxidase B activity, tissue inhibitor of metalloproteinase I (TIMP), procollagen typeⅢN-terminal peptide, collagen type Ⅳ, hyaluronic acid and laminin, as well as increase the excretion of droxyproline markedly. As compared with control group, the difference between the two groups were significant except the change of TIMP,the improvement of 319 Recipe group were more obvious than that of control group (P <0 . 001 ̄ 0 . 05). These results displayed the good effect of 319 Recipe in treating chronic hepatitis B and preventing the development of hepatic fibrosis.
出处
《中国中西医结合杂志》
CSCD
北大核心
1996年第10期588-592,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家"八五"科技攻关资助
关键词
慢性
乙型肝炎
肝纤维化
扶正化瘀
中医药疗法
chronic hepatitis B
hepatic fibrosis
supplement body resistance and remove blood stasis
collagen type Ⅳ
hyaluronic acid
tissue inhibitor of metalloproteinase type I