乳腺康对乳腺增生病患者垂体—性腺激素周期节律的影响

Effect of Ruxiankang on Rhythm of Pituitary Sex Hormone Secretion in Patients of Mammary Gland Hyperplasia

对２３例乳腺增生病患者治疗前后卵泡期、排卵期、黄体期及月经前期血清中雌激素、孕激素、促黄体生成素、促卵泡激素和催乳素进行了测定，并与１５例健康人的测定结果对照。结果显示：健康人除催乳素外，其他垂体－性腺激素都有明显的周期节律变化；乳腺增生病患者垂体和性腺激素分泌节律紊乱，孕激素分泌时间延长，雌激素分泌在卵泡期和月经前期增高，而在排卵期降低，促黄体生成素和促卵泡激素分泌在排卵期均降低，而在黄体期却增高。经用乳腺康治疗２～３个月后，垂体和性腺激素分泌节律趋于正常。孕激素在月经前期回复到最低点，雌激素在卵泡期和月经前期降低，而在排卵期明显升高，促黄体生成素和促卵泡激素在排卵期出现一个接近正常的分泌峰。本研究认为，乳腺康中的二仙汤可以调整性激素的周期性节律；而乳腺康中的逍遥散可以调节肝脏对激素的灭活功能。

The estrogen, progesterone, luteinizing hormone, follicle stimulating hormone and prolactin of 23 patients with hyperplasia of mammary gland and 15 healthy persons were measured and compared. Results showed that there were significant periodical rhythmic changes in pituitary-sex hormones in normal persons except prolactin.The secretory rhythm of patients disturbed with elongation of secretory time of progesterone, secretion of estrogen decreased during ovulatory phase and increased during follicular and premenstrual phases, luteinizing hormone and follicle stimulating hormone decreased during ovulatory phase and increased during luteal phase. After treatment with Ruxiankang for 2￣3 months the pituitary-ovarian turned to normal. Secretion of progesterone reduced to the lowest level during premenstrual phase, secretion of estrogen decreased during the follicular and premenstrual phases and increased during the ovulatory phase, secretory peak of luteinizing hormone and follicle stimulating hormone presented normalization of ovulatory phase. These results indicated that the Erxiantang, part of the ingredients of Ruxiankang, could adjust the periodic rhythm of sex hormones secretion and Xiaoyaosan, another part of the ingredients of Ruxiankang, could regulate the liver function of hormone inactivating.