高山红景天多糖降血糖作用——不同给药途径的比较

Studies on Hypoglycemic Effect of Rhodiola sachalinensis A.Bor. Polysaccharides:Comparison of Administration in Different Ways

分别给小鼠腹腔注射ＲＳＰＡ和Ｂ各１００，５０ｍｇ／ｋｇ，结果表明ＲＳＰＢ为高山红景天降血糖作用的有效部分，经多种途径给药证明ＲＳＰＢ不能经胃肠吸收而发挥降血糖作用，但经ｓｃ，ｉｍ，ｉｐ。

When Rhodiola sachalinensis polysaccharides A and B (RSP A and RSP B)were intraperitoneally injected to mice at dosages of 50mg/kg and 100mg/kg,the result showed that RSP B was the effective hypoglycemic ingredient of Rhodiola sachalinensis .When mice were administrated in different ways,it was shown that RSP B did not possess significant hypoglycemic effect through absorption in the instestines.However,RSP B does possess significant hypoglycemic effect if administrated subcutaneously,intramuscularly,intraperitoneally and intravenously.