严重烫伤大鼠肠粘膜通透性改变及其机理

A study on changes and its mechanisms of intestinal mucosal permeability after severe burn

采用^(99m)Tc-DTPA 血至肠腔清除率定量测定方法,观察大鼠严重烫伤后肠粘膜通透性的变化规律及血小板活化因子(PAF)对其产生的影响,以探讨严重烫伤后肠粘膜屏障功能损害的病理生理过程及机理。结果表明:严重烫伤后肠粘膜通透性显著升高,与肠组织 PAF 含量升高呈显著正相关(r=0.94,P<0.01),PAF 拮抗剂治疗能明显降低肠粘膜通透性。提示,PAF 是导致严重烫伤后肠粘膜通透性升高的重要因素之一。

The changes in the intestinal mucosal permeability were observed by quantitatively as- sessing plasma to luminal clearance of ^(99m)Tc—labeled DTPA,and the influence of platelet activating fac- tor(PAF)on it was investigated.The results showed that intestinal permeability was significantly ele- vated after severe burn and was positively correlated with increase in PAF in the intestinal tissue(r= 0.94,P<0.01).PAF antagonist therapy could significantly attenuate postburn intestinal mucosal per- meability.It is concluded that PAF is one of the important factors causing increased intestinal permeabil- ity after severe burn.