摘要
为研究烧伤后肠道分泌 S—IgA 的变化,利用30%Ⅲ度小型香猪烧伤动物模型,动态观察了早期肠道营养液中加入谷氨酰胺对肠道分泌 S—IgA 的影响,结果显示:未补充谷氨酰胺的动物空肠和回肠液中 S—IgA 的含量在伤后明显降低,动脉血中 IgA 的含量也明显降低,而补充谷氨酰胺的动物空肠、回肠液中的 S—IgA,以及动脉血中的 IgA 均明显高于未补充的动物,且与伤前无明显差别。提示早期肠道营养液中加入谷氨酰胺能明显维护肠粘膜细胞分泌 S—IgA 的功能,对防治烧伤后细菌或毒素移位有重要意义。
In order to investigate the effect of L—glutamine on gut immune function,14 miniswines with 30% TBSA full thickness burns were randomly and equally divided into NON—GLN gronp and GLN group.GLN group animals were supplied with L—glutamine 0.64g/day,and NON—GLN group received equal amount of non—glutamine amino acids.The S—IgA concentration of jejunal and IgA concentration of arterial blood were determined on PBD (post burn day)1,4,7,10.S—IgA concentration of ileal contents was measured on PBD10.The results showed that the concentrations of S—IgA in the jejunal and ileal con- tents as well as IgA in arterial blood decreased significantly after burns in NON—GLN group.L—glu- tamine supplement increased the excretion of S—IgA of intestinal mucosa in the GLN group.This result suggests that oral feeding of L—glutamine improves the intestinal S—IgA excretion after burns efficiently, and it plays an important role in the prevention of endotoxin and bacterial translocation after burns.
