摘要
利用大鼠30%Ⅲ度烧伤模型,探讨了烧伤大鼠心肌组织唾液酸含量的变化,同时还观察了心肌组织三磷酸腺苷酶(ATPase)活性和 Ca^(2+)含量改变。结果表明:烧伤后大鼠心肌组织唾液酸显著降低,伤后3小时仅为对照组的58.8%。同时心肌组织 Na^+、K^+-ATPase,Mg^(2+)-ATPase和 Ca^(2+)-ATPase 活性降低,而 Ca^(2+)含量明显升高。提示:唾液酸含量与心肌膜结构和功能有密切关系。组织唾液酸含量的减少可能是造成烧伤后能量代谢紊乱,ATPase 功能降低以及钙超载的重要因素之一。
The myocardial sialic acid content,ATPase activities,and Ca^(2+) level were investigated in rats with full thickness burn of 30% TBSA.The results showed that the burned rats had a decreased level of myocardial sialic acid which was only 58.8% of controls at 3 h postburn.Myocardial Na^+ ,K^+- ATPase,Ca^(2+),Mg^(2+)-ATPase and Ca^(2+)-ATPase activities were inhibited in burned rats.As compared to controls,the burned rats showed a higher level of Ca^(2+) in heart tissue.This study indicated that there were abnormal energy metabolism,dysfunction of ion pump,and paradox Ca^(2+) overload in burned rats, which may be associated with the decrease in sialic acid content in myocardium.
基金
国家自然科学基金
