慢性肝炎患者肝损害程度与血清中TNF-α、IL-6、IL-8含量的相关性

Relation between different levels of TNF -α、IL-6、IL-8 in serum and damages of liver tissue in patients with chronic viral hepatitis B

观察急、慢性肝炎患者血清HBV DNA含量及肝脏损害程度与血清中TNF-α、IL-6、IL-8含量的相关性。对急、慢性乙型肝炎患者264例均作肝穿观察肝组织损害程度,并检测血清HBVDNA定量、TNF-α、IL-6及IL-8的含量。(1)血清中TNF-α、IL-6、IL-8水平与HBVDNA含量呈正相关。(2)乙型肝炎患者间随着肝脏损害程度的加重,其血清中的TNF-α、IL-6、IL-8的含量也随之增多。乙型肝炎患者随着体内病毒含量的增加及肝脏损害程度的加重,其血清中的TNF-α、IL-6、IL-8的含量也随之增加。血清TNF—α、IL-6、IL-8水平的高低能够反应肝细胞的损害程度,同时也说明TNF-α、IL-6、IL-8参与了病毒性肝炎的发病机理。

To observe the relation between quantities of TNF -α ,IL- 6 ,IL -8 in serum and different damages of liver tissue in patients with hepatitis. The quantities of TNF -α ,IL- 6 ,IL- 8 were detected by ELISA, the DNA of virus was detected by amplisensor PCR assay system, the damages of liver tissue was detected by pathology. The statistics was tested. The quantities of TNF -α,IL -6 ,IL -8 and virus in serum were increased in patients with hepatitis B than that in control （P〈0.01）.