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脐血干细胞向肝系细胞分化的研究进展 被引量：1

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摘要 干细胞是一类具有自我增殖能力和多向分化潜能的细胞，按照其来源可以分为胚胎干细胞（embryonic stem cells，ESC）和成体干细胞（somatic／adultstemcells）。ESCs来源于人或动物的胚胎内细胞团或原始生殖嵴，在体内外能分化为三个胚层的所有组织细胞，但其研究及应用受到伦理学的限制。成体干细胞是分布在已分化特定组织中的未分化细胞，它具有自我更新的能力，并能产生由它来源的所有特定类型的组织细胞，其来源包括骨髓、血液、肝脏、皮肤等。目前研究发现，成体干细胞不仅能生成其来源组织的所有特化细胞，还能分化为其它组织的细胞，即所谓的“横向分化”（trans-differentiation）。
作者 熊中华 赵连三 陆德云
机构地区 四川大学华西医院感染性疾病中心生物治疗国家重点实验室
出处 《临床肝胆病杂志》 CAS 2006年第4期299-300,共2页 Journal of Clinical Hepatology
关键词 肝系细胞分化 脐血干细胞 成体干细胞 胚胎干细胞 组织细胞 多向分化潜能 “横向分化” 增殖能力 cells 未分化细胞
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献14

  • 1Daley GQ,Goodell MA,Snyder EY.Realistic prospects for stem cell therapeutics[J].Hematology,2003,398-418.
  • 2Erices A,Conget P,Minguell JJ,et al.Mesenchymal progenitor cells in human umbilical cord blood[J].Br J Haematol,2000,109(1):235-242.
  • 3Kim JW,Kim SY,Park SY,et al.Mesenchymal progenitor cells in the human umbilical cord[J].Ann Hematol,2004,83 (12):733 -738.
  • 4许倩,赵连三,王丽春,汪成孝,贺茜,刘丽,吴雄志,于晓辉.人脐带血间充质干细胞分离培养的技术初探[J].华西医学,2005,20(2):285-287. 被引量：13
  • 5Goodwin HS,Bicknese AR,Chien SN,et al.Multilineage differentiation activity by cells isolated from umbilical cord blood:expression of bone,fat,and neural markers[J].Biol Blood Marrow Transplant,2001,7(11):581 -588.
  • 6Kong KY,Ren J,Kraus M,et al.Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice[J].Stem Cells,2004,22(6):981 -993.
  • 7Lee OK,Kuo TK,Chen WM,et al.Islation of multipotent mesenchymal stem cells from umbilical cord blood[J].Blood,2004,103(5):1669-1675.
  • 8Kogler G,Sensken S,Airey JA,et al.A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential[J].J Exp Med,2004,200(2):123-135.
  • 9Kakinuma S,Tanaka Y,Chinzei r,et al.Human Umbilical Cord Blood as a Source of Transplantable Hepatic Progenitor Cells[J].Stem Cells,2003,21 (2):217-227.
  • 10Newsome PN,Johannessen I,Boyle S,et al.Human cord bloodderived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion[J].Gastroenterology,2003,124 (7):1891-1900.

二级参考文献12

  • 1Erices A,Conget P,Minguell JJ.Mesenchymal progenitor cells in human umbilical cord blood[J].Br J Haematol,2000,109(1):235-42.
  • 2Lee OK,Kuo TK,Chen WM,et al.Isolation of multipotent mesenchymal stem cells from umbilical cord blood[J].Blood,2004,103(5):1669-1675.
  • 3Bieback K,Kern S,Kluter H,et al.Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood[J].Stem Cells, 2004,22(4):625-634.
  • 4Gang EJ,Jeong JA,Hong SH,et al.Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood[J].Stem Cells,2004,22(4):617-624.
  • 5Erices A,Conget P,Minguell JJ.Mesenchymal progenitor cells in human umbilical cord blood[J].Br J Haematol,2000,109(1):235-242.
  • 6Bieback K,Kern S,Kluter H,et al.Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood[J].Stem Cells,2004;22(4):625-634.
  • 7Healy L,May G,Gale K et al.The stem cell antigen CD34 function as a regulator of hemopoietic cell adhesion[J].Proc Natl Acad Sci USA,1995,92(10):12240-12244.
  • 8Anderson DJ,Gage FH,Weissman IL,et al.Can stem cells cross lineage boundaries? Nature Med,2001,7:393-395.
  • 9Erices A,Conget P,Minguell.Mesenchymal progenitor cells in human umbilical cord blood.Br J Haematol,2000,109:235-242.
  • 10Newsome PN,Johannessen I,Boyle S,et al.Human cord blood-derived cells can differentiation into hepatocytes in the mouse liver with no evidence of cellular fusion.Gastroenterology,2003,124(7):1891-1900.

共引文献34

同被引文献42

  • 1唐晓鹏,杨旭,张旻,王文龙,陈丽敏.脐血干细胞移植治疗肝功能衰竭及心肌损害的临床与实验研究[J].中华肝脏病杂志,2005,13(4):259-263. 被引量：32
  • 2许倩,赵连三,王丽春,汪成孝,贺茜,刘丽,吴雄志,于晓辉.人脐带血间充质干细胞分离培养的技术初探[J].华西医学,2005,20(2):285-287. 被引量：13
  • 3Bilir BM,Guineitte D,Karrer K,et al.Hepatocyte transplantation in acute liver failure.Liver Transplant,2000,6 (1):32-40.
  • 4Strom SC,Fisher RA,Thompson MT,et al.Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure.Transplantation,1997,63(4):559-569.
  • 5Suzuki A,Nakauchi H,Taniguchi H.In vitro production of functionally mature hepatocytes from prospectively isolated hepatic stem cells.Cell Transplant,2003,12 (5):469-473.
  • 6Goodell MA.Stem-cell "plasticity":befuddled by the muddle.Curr Opin Hematol,2003,10(3):208-213.
  • 7Avital I,Inderbitzin D,Aoki T,et al.Isolation,characterization,and transplantation of bone marrow-derived hepatocyte stem cells.Biochem Biophys Res Commun,2001,288 (1):156-164.
  • 8Kodama S,Kuhtreiber W,Fujimura S,et al.Islet regeneration during the reversal of autoimmune diabetes in NOD mice.Science,2003,302 (5648):1223-1227.
  • 9Alvarez-Dolado M,Pardal R,Garcia-Verdugo JM,et al.Fusion of bone-marrow-derived cells with Purkinje neurons,cardiomyocytes and hepatocytes.Nature,2003,425 (6961):968-973.
  • 10Wang X,Willenbring H,Akkari Y,et al.Cell fusion is the principal source of bone-marrow-derived hepatocytes.Nature,2003,422(6934):897-901.

引证文献1

二级引证文献3

临床肝胆病杂志
2006年 第4期

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