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激活素A信号调控与肝脏疾病 被引量:4

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摘要 激活素A是一种多功能细胞因子,具有广泛生物学作用,其在肝脏的作用主要表现为抑制细胞增殖、诱导细胞凋亡、促进细胞外基质分泌、抑制肿瘤细胞增殖及转移。在慢性肝炎、肝纤维化、肝癌及肝功能衰竭等疾病发生发展过程中均有激活素A表达异常,提示激活素A信号异常可能参与了肝脏疾病发生发展过程。
出处 《临床肝胆病杂志》 CAS 2006年第4期314-315,共2页 Journal of Clinical Hepatology
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参考文献16

  • 1Luisi S,Florio P,Reis FM,et al.Expression and secretion of activin A:possible physiological and clinical implications[J].Eur J Endocrinol,2001,145(3):225 -236.
  • 2Chen YG,Lui HM,Lin SL,et al.Regulation of cell proliferation,apoptosis,and Carcinogenesis by activin[J].Experimental Biology and Medicine,2002,227(2):75 -87.
  • 3Locaputo S,Carrick TL,Bezerra JA.Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice[J].Hepatology,1999,29(4):1106-1113.
  • 4Hughes RD,Evans LW.Activin A and follistatin in acute liver failure[J].Eur J Gastroenterol Hepatol,2003,15 (2):127-131.
  • 5Patella S,Phillips DJ,de Kretser DM,et al.Characterization of serum activin-A and follistatin and their relation to virological and histological determinants in chronic viral hepatitis[J].J Hepatol,2001,34(4):576-583.
  • 6Sugiyama M,Ichida T,Sato T,et al.Expression of activin A is increased in cirrhotic and fibrotic rat livers[J].Gastroenterology,1998,114(3):550-558.
  • 7Date M,Matsuzaki K,Matsushita M,et al.Differential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury[J].J Hepatol,2000,32(2):251-260.
  • 8Rossmanith W,Chabicovsky M,Grasl-Kraupp B,et al.Follistatin over-expression in rodent liver tumors:a possible mechanism to overcome activin growth control[J].Mol Carcinog,2002,35(1):1-5.
  • 9Lee DK,Park SH,Yi Y,et al.The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4:potential mechanism of hepatitis B virus-induced liver fibrosis[J].Genes Der,2001,15 (4):455-466.
  • 10Caselitz M,Chavan A,Manns MP,et al.Hereditary hemorrhagic telangiectasia (Osler-Reudu-Weber disease) and its manifestation in the liver[J].Z Gastroenterol,2001,39(7):533 -542.

同被引文献5

  • 1张红军,台桂香,杨清,柳忠辉.激活素在肝纤维化形成中的作用[J].临床肝胆病杂志,2007,23(3):232-234. 被引量:8
  • 2MI LJ,MAK KM,LIEBER CS.Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC)[J].Alcohol clin Exp Res 2000,24(2):207.
  • 3TSUCHIDA K,NAKATANI M,MATSUZAKI T.Novel factors in regulation of activin signaling[J].Mol cell Endocrinol,2004,225:1.
  • 4Mi LJ,Mak KM,Lieber CS.Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC)[J].Alcohol clin Exp Res,2000,24(2):207.
  • 5中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量:14010

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