洛伐他汀治疗不稳定型心绞痛的疗效及对炎症因子的影响

Effects of Lovastatin on Inflammation Factor in Patients with Unstable Angina

目的观察洛伐他汀治疗冠心病不稳定型心绞痛(UA)的疗效及对炎症因子C-反应蛋白(CRP)和纤维蛋白原(FG)浓度的影响。方法60例UA患者分为治疗组和对照组,均进行常规治疗,治疗组在常规治疗基础上加用洛伐他汀治疗。观察两组用药前后有血脂、C反应蛋白(CRP)、纤维蛋白原(FG)的水平和急性冠脉事件发生情况。结果治疗前两组的血脂、CRP、FG水平差异均无显著性(P>0.05),治疗后治疗组的血脂、CRP、FG水平低于对照组(P均<0.01)。急性冠脉事件发生率较对照组低(P<0.05)。结论洛伐他汀可降低UA患者血脂及FG、CRP水平及降低冠状动脉事件的发生。

To observe the clinical effects on patients with unstable angina（UA）.Methods Sixty cases with UA were divided into two groups： therapy group and control group. Both groups were treated with the same basical methods. But lovastafin was administered in therapy group.The period of treatment was 24 weeks.The levels of blood- lipid, C- reactive protein（CRP） ,fibrinogen（FG） and the incidence of ischemic events in 60 cases were observed before and after treatment. Results The levels of blood - lipid, CRP and FG, and the incidence of ischemic events in therapy group were significantly lower than those in the control group. Condusion Lovastatin can reduce blood- lipid, inhibit inflammation factor, decline the cardiovascular events in patients with UA.