速碧林联合异舒吉治疗不稳定型心绞痛的临床观察

Clinical Observation on Unstable Angina Treated with Fraxiparine and Isosorbide Dinitrate

目的 观察速碧林（低分子肝素钙）联合异舒吉（二硝酸异山梨醇酯注射液）治疗不稳定型心绞痛的疗效。方法 48例不稳定型心绞痛病人随机分成治疗组与对照组，对照组进行常规治疗，治疗组在常规治疗的基础上，用异舒吉20nag加入5％葡萄糖注射液250mL中静脉注射（40-80μg／min），1次/d；速碧林0.4mL皮下注射，2次／d，3d后停药。观察心电图，心绞痛发作的次数、强度及血液流变学参数。结论 速碧林联合异舒吉能很好地控制不稳定型心绞痛的发作，预防AMI的发生，且无明显的毒副作用，值得推广使用。

Objective To observe the curative effect of unstable angina treated with fraxiparine and isosorbide dinitrate.Methods 48easesof unstable angina patient were divided into therapy group and control group. The control group was treated with routinely. The therapy group was treated with isosorbide dinitrate 20 mg intravenously and fraxiparine 0.4 mL subcutaneously b. i. d for 3 days. The ECG, episode times, strength and rheology were detected .Results There was significant difference between therapy group and control group in curative effect. Conclusion The fraxiparine and isosorbide dinitrate combination might control the episode of unstable angina and prevent AMI without side effect.