甘利欣联合优思弗治疗慢性乙型肝炎的疗效观察

Observing the Effect of Glycyrrhizinate Comownd Ursodeoxycholi acid on Treating Chronic Hepatits B

目的:观察优思弗联合甘利欣胶囊治疗慢性乙型肝炎的疗效。方法:87例慢性乙型肝炎患者均为抗病毒治疗失败或肝功能长期异常者,随机分为治疗组(47例)和对照组(40例),分别给予甘利欣胶囊联合优思弗胶囊和复方甘草酸苷+维生素C治疗,疗程均为8wk。结果:治疗组在肝功能、免疫功能改善方面优于对照组(P<0.05);治疗组与对照组总有效率分别为89.4%、67.5%(P<0.01)。结论:甘利欣联合优思弗治疗抗病毒失败或肝功能长期异常者有效。

Objective： To observe the therapeutic effect of compound glycyrrhizin combining ursodeoxy - cholic acid in the treatment of chronic hepatitis B. Method： 87 patients with chronic hepatitis B were enrolled to, on whom, the anti - viral therapy proved to be ineffective and who suffered a long - term abnormal liver functions, of the total ,47 were randomly assignesd to receive compound glycyrrhizin plus ursodeoxycholic acid （treatment, group）, and 40 to receive compound glycyrrhizin plus vitamin C （ control group ）. Course of treatment for both groups was 8 weeks. Result： As compared with the control group, the liver function and immune function for the treatment group had a better amelioration （ P 〈 0.05 ） ; the total effective group, the liver function and immune control group were 89.4% and 67.5% （P 〈0.01）, respectively. Conclusion： Compound glycyrrhizin plus ursodeoxycholi acid is effective in treatment of chronic hepatitis B cases when anti - viral therapy is ineffective and whose liver function are abnormal for a long time.