摘要
目的系统评价水蛭治疗缺血性中风急性期的疗效及安全性。方法检索水蛭治疗缺血性中风急性期随机对照试验文献,制定选择标准,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta-分析、漏斗图分析、敏感性分析等方法统计相关数据。结果3项研究符合纳入标准,Jadad评分所有研究得分均低于3分,属低质量文献。Meta-分析结果显示,总有效率比较的相对危险度(RR)为1.17,99%的可信区间(CI)为(1.02,1.35);恶心呕吐发生率为5.41%,与空白对照比较,其RR(99%CI)为5.00(0.10,258.76)。结论Meta-分析结果显示水蛭具有改善缺血性中风急性期患者神经功能缺损状况的作用,且安全性较高。
Objective It is to evaluate systematically efficacy and safety of hirudo for acute ischaemic stroke. Methods Randomized controlled trails (RCTs) of hirudo for acute ischaemic stroke were identified, eligible studies were included, the methodological quality of inclusive trails was assessed by Jadad scale. Heterogeneity test, funnel plot analysis and sensitivity analysis were used to analyse data. Results Three RCTs were included, Jadad scale of all study were small than 3, with all trails of low methodological quality. Meta-analysis indicated that relative risk of overall effective rate of hirudo group was 1.17(99 % CI (1.02, 1. 35) ), that of control group was 5.00 (0.10, 258.76). Conclusion This systematic review shows that hirudo is effective and safety for acute ischaemic stroke.
出处
《现代中西医结合杂志》
CAS
2006年第17期2311-2312,2314,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
国家中医药管理局资助课题(04-05LQ03)
关键词
水蛭
缺血性中风
急性期
随机对照试验
系统评价
hirudo
acute ischaemic stroke
randomized controlled trail
systematic review