32例胃肠道间质瘤临床病理及免疫组化观察

Clinicopathologic and Immunohistochemical Observation of 32 cases on Stromal Tumors of the Gastric-intestinal Ttract

目的 观察胃肠道间质瘸的临床及病理形态学特点并探讨其组织发生,方法 对32例胃肠道间质瘸进行光镜观察及免疫组化染色。结果 32例胃肠道间质瘸中，发生于胃21例，小肠8例，直肠1例，肠系膜2倒。发病高峰年龄50-70岁。镜下观察，良性间质瘸3例，低度恶性潜能间质瘸20例，恶性间质瘸9倒。免疫组化染色CD-117弥漫强阳性（27例）。结论 胃肠道间质瘸是一种免疫表型上表达KIT蛋白（CD-117）、组织学上以富于梭形细胞或上皮样细胞的间叶泺性肿瘸，谈肿瘸生物学行为以潜在恶性和恶性为主。

Objective To investigate the clinicopathological characteristics of gastrointestinal strornal tumors （GISTs） and to discuss its histogenesis. Methods 32 cases of GISTs were investigated at the light microscopic level and studied by immunohistochemical technique. Results The age of 32 cases with GISTs ranged from 50 to 70 years. Among these cases,21 were located in the stomach,8 in the small intestine, one in the rectum, 2 in the mesenteric. The histopathological features were as follows. Three cases of the benign stromal tumors, 20 cases of the borderline strornal tumors, 9 cases of the malignant stromal tumors. 27 cases of all the stromal tumors were strongly positive staining for CD-117. Conclusions GISTs are the most common group of mesenchymal tumors seen in the alimentary tract. Immunohistochemical,c-kit（CD-117） showed strong express. Histologically, the tumor shows two basic cell types spindle and epithelioid. Biological behaviorally, the tumor compose mostly two classifications potential malignant.