白花前胡浸膏对肾型高血压左室肥厚大鼠的血压、左室肥厚形成及血流动力学的影响

Effects of Peucedanum Praeruptorum Extractum on Blood Pressure,Left Ventricular Hypertrophy and Hemodynamic Changes in Left Ventricular Hypertrophied Hypertensive Rats

白花前胡浸膏能降低正常大鼠和肾型高血压大鼠的血压，可预防肾型高血压大鼠左室肥厚的形成，左室重／体重较高血压左室肥厚对照组明显降低，与假手术对照组无明显差异；白花前胡浸膏组对离体工作心脏的血流动力学改变较未治疗组显著改善，尤其是冠脉流量显著增多。

After intragastric administration of Peucedanum praeruptorum(PPE) 0 . 6 g/100 g body weight,the blood pressure was decreased significantly in both the normal and the left ventricular hypertrophied hypertensive (LVH) rats. The PPE could still prevent the formation of the left ventricular hypertrophy in renovascular hypertensive rats, the ratio of weight of left ventricular over the weight of body was reduced markedly than that of the LVH group, and was nearly the same of the sham-operated group. The PPE could improve both the systolic and diastolic function than that of the LVH group in the isolated heart, especially, the flow of the coronary artery was increased significantly.