麝香保心丸改善心肌缺血作用的核心脏影像学研究

Study on Heart-protecting Musk Pill in Improving Myocardial Ischemia Evaluated by Nuclear Myocardial Imaging

在１７例冠心病患者中应用静脉注射潘生丁心肌^（９９ｍ）锝－甲氧异丁异晴单光子发射计算机断层显像术（下称ＳＰＥＣＴ）观察麝香保心丸（下称保心丸）含服后对心肌缺血区血流灌注的影响。结果：含服保心丸后静脉注射潘生丁引起的心脏副作用的症状缓解率为８５％；可逆性影像缺损组１１例中有８例及固定性影像缺损者６例中的４例ＳＰＥＣＴ影像明显改善，提示保心丸可改善心肌缺血区血流灌注，总有效率为７０．６％未观察到任何保心丸引起的副作用。

The effect of Heart-protecting Musk Pill(HMP) on blood perfusion of the ischemic myocardium by intravenous dipyridamole 99m Tc-MIBI single photon emission computerized tomography(SPECT) in 17 patients with coronary heart disease was observed.Results showed that sublingual administration of HMP prior to injection of dipyridamole could remit the cardiac symptoms induced by dipyridamole,such as angina, chest distress,etc.With a remission rate of 85%.HMP could also improve the SPECT image defect significantly,8 of 11 cases wich reversible image defects and 4 of 6 irreversible image defects were improved.It suggested that HMP could improve the blood perfusion of the ischemic myocardium,the total effective rate was 70.6o%.No adverse reaction was found.