保元强肾Ⅰ号片延长终末期肾病血透间期研究

Study on Effect of Baoyuan Qiangshen Tablet No.Ⅰin Prolongating Interval of Hemodialysis in Patients of Terminal-Stage of Renal Disease

对２０例终末期肾病（ＴＳＲＤ）患者，采用保元强肾Ⅰ号片联合５天１次血液透析（血透）的中西医结合治疗组（中西组），并与３天１次的常规血透组（对照组）比较，结果中西组血透间期ＳＣｒ、ＢＵＮ上升幅度显著低于对照组（Ｐ＜０．０１），经３个月治疗后，中西组ＳＣｒ、ＢＵＮ均比治前明显降低（Ｐ＜０．０１），但ＣＣｒ治疗前后无显著差异（Ｐ＞０．０５）。血浆白蛋白、脂蛋白、尿前列腺素及贫血均有不同程度改善。提示保元强肾Ⅰ号片可能通过调整脂质紊乱，延长慢性肾衰的进展，保护残余肾单位功能，从而起到延长血透间期，减少血透次数的作用。

Twenty cases of terminal stage of renal disease(TSRD) were treated with Baoyuan Qiangshen Tablet No.Ⅰ(BYQS Ⅰ) combined with hemodialysis once every 5 days(TCM-WM group) was observed and compared with patients treated with routine hemodialysis(once every 3 days) only(control group).Results showed that the increaseing extents of serum creatinine,blood urea nitrogen of TCM-WM group at dialysis interval were all lower than that of control group(p<0.01).After 3 months,treatment,serum creatinine,blood urea nitrogen of TCM-WM group were lower than that before treatment,plasma albumin,lipoprotein, urine level of prostaglandin and anemia were all improved to varies extent,but the creatinine clearance rate was unchanged.The author considered that BYQS Ⅰ could prolong the interval and reduce the times of dialysis by way of regulating the lipid metabolism disorder,improving pathological change of kidney and protect function of residual kidney unit, and above-mentioned therapeutic method is a good programm of integrated TCM-WM in treating TSRD.