补肾方加全胎液治疗肾性贫血的临床与实验研究

Clinical and Experimental Study of Kidney Tonics Plus Whole Embryo Extract in Treatment of Renal Anemia

本研究对肾性贫血患者以中医补肾气、益精血为治则，制定了中药复方制剂肾性贫血Ⅰ号冲剂（养阴为主），肾性贫血Ⅱ号冲剂（温阳益肾为主）进行治疗。临床上分为加服全胎液（组Ⅰ）及不加服全胎液（组Ⅱ）两组，进行辨证治疗。经３０例治疗前后比较和动物模型的实验研究。结果临床观察组Ⅰ治疗前后血清红细胞生成素、血红蛋白均有显著差异（Ｐ＜０．０５），动物模型的血红蛋白治疗组较对照组亦有明显提高（Ｐ＜０．０５），提示本法对骨髓造血系统有一定促进作用。

According to the therapeutic principles,reinforcing Kidney-Qi and nourishing the blood were used in treating renal anemia,Renal Anemia Granule No.Ⅰ and No.Ⅱ(RAG Ⅰ and Ⅱ) were applied in treating patients of renal anemia,the former was a Yin reinforcing agent and the latter a Yang tonics principally.Thirty patients were treated according to the Syndrome Differentiation of TCM and divided into two groups:(1) The combined group,oral liquid of the whole embryo extract was given additionally.(2)The discombined group,no additional drug was given.Patients after treatment all showed significant improvements in serum erythropoietin and hemoglobin(p<0.05).Experimantal study in animal models also displayed the hemoglobin of treated group increased more than that of control group(P<0.05),which might be related to the enhancement of hematopoietic function of bone marrow.