血浆α－颗粒膜蛋白140测定在原发性肾小球疾病血瘀证中的临床意义

Clinical Significance of Plasmaα-Granule Membrane Protein-140 in Blood Stasis of Primary Glomerular Disease

本研究测定５３例血瘀证和非血瘀证原发性肾小球疾病（ＰＧＤ）患者血浆α－颗粒膜蛋白１４０（ＧＭＰ－１４０）浓度，并观察ＰＧＤ患者中高血脂、高血压与ＧＭＰ－１４０的关系。结果显示：ＰＧＤ患者血浆ＧＭＰ－１４０浓度明显高于对照组（Ｐ＜０．０１），血小板处于高度活化状态，其中血瘀证组显著高于非血瘀证组（Ｐ＜０．０１），血瘀证患者中气虚组高于非气虚组（Ｐ＜０．０５），说明ＧＭＰ－１４０是反映ＰＧＤ血瘀证的客观指标，气虚能加重血小板活化，加重血瘀倾向，符合中医“气虚血瘀”理论。高血脂、高血压与ＧＭＰ－１４０异常增高密切相关，是造成ＰＧＤ高凝状态、血瘀倾向的重要因素。

Plasma a-granule membrane protcin 140(GMP-140) was determined in 53 patients of primary glomerular disease(PGD) with or without blood stasis.At the same time,the relationships between plasma GMP-140 and hyperlipoidemia and hypertension were investigated. Results showed that plasma GMP-140 in PGD patients was higher than that of normal control subjects,P<0.01, platelet of patients was in a high activated status.The elevation was more significant in patient with blood stasis than in those without blood stasis,P<0.01.Among the patients with blood stasis,plasma GMP-140 level in those with Qi-Deficiency was higher than that without Qi-Deficiency(P<0.05)The above-mentioned results suggested that GMP- 140 was an objective indicator for blood stasis of PGD patients.Deficiency of Qi could enhance platelet activation so as to aggravate the tendency of blood stasis.It was in accordance with the traditional Chinese medicine theory of "Qi-Deficiency induces blood stasis".Hyperlipoidemia and hypertension showed close relationship with abnormalincrease of GMP-140,suggesting they play important roles in induction of hypercoagulability and blood stasis in PGD patients.