镇咳灵口服液治疗儿童咳嗽的临床及实验研究

Clinical and Experimental Studies of Zhenkeling Oral Liquor on Treatment Infantile Cough

将１７０例咳嗽患儿随机分为两组，镇咳灵口服液组（镇咳灵组）１２０例，小儿止咳化痰糖浆组（对照组）５０例。结果镇咳灵组及对照组总有效率分别为９６．７％、５６．０％。愈显率分别为８０．８％、１８．０％（Ｐ均＜０．００１）。动物实验结果表明，镇咳灵口服液有明显的镇咳、祛痰及平喘作用，并有抗炎及抗菌作用。急性及慢性毒性实验表明该药无任何毒副作用。

One hundred and seventy children with cough were divied into two groups at random.120 patient were treated with Zhenkeling oral liquor(ZKL group).The other 50 children were given pectoral syrup(control group).The results showed that the total effective rates of ZKL group and control group were 96.7% and 56. 0% respectively,and the markedly effective rates were 80.8%,18.0% respectively(P<0.001).Animal experiments indicated Zhenkeling has the effect of relieving cough,reducing sputum and ameliorating asthma,their antibiotic and anti-inflammatory effects were discovered too.The dosage of Zhenkeling was 100 times as clinical dose in acute toxicity test and the dosage was 32,16,8 times as clinical dose in long term toxicity test respectively.No adverse action was found in these experiments.