心衰康冲剂对实验性兔心力衰竭心功能及心钠素的影响

Effects of Xinshuaikang Granule on Cardiac Function and Atrial Natriuretic Polypeptide Levels in Rabbits with Experimental Congestive Heart Failure

以红参、附子、川芎、葶苈子等药制成心衰康冲剂。选用３５只日本大耳白兔，随机分为５组，其中４组由耳缘静脉注射盐酸阿霉素造成充血性心力衰竭，以心衰康大剂量、小剂量作为治疗组，以心宝为治疗对照组，１５天为１个疗程。结果表明：造模后各组体重均有所增加，以造模组体重增加最为明显；心衰康及心宝均可明显降低兔的体重，改善一般状况，减慢心率，提高心脏功能，降低血浆心钠素水平，以心衰康大剂量的效果最好，心衰康小剂量与心宝作用相当。说明心衰康能改善充血性心力衰竭兔的心脏功能及心脏的内分泌功能，对充血性心力衰竭有一定的疗效。

Xinshuaikang(XSK) granule mainly consisted of Radix Ginseng,Aconifum carmichaeli,Ligustici wallichii,Semen Lepidii seu Descurainiae,etc.Thirty-five white rabbits of Japanese strain with big ears were used and five groups were divided randomly.The models of chronic heart failure(CHF)was made by injection of adriamycin through the marginal vein of rabbit's ear.Only one group without adriamycin injection was taken as blank group.After the making of models,Xinbao(XB) was used to treat one group which was regarded as control group,XSK was used to treat two model groups,one used higher dose,the other one used lower dose.Fifteen days was taken as a course of treatment.The results were:the body weight of all model groups was heavier than that without adriamycin.After a course of treatment,the body weight of the groups treated by XSK or XB decreased rapidly,the general conditions of the three groups were improved;the two drugs could reduce heart rate and enhance heart function,at the same time they reduced the level of atrial natriuretic polypeptide(ANP) in plasma.The best results was obtained in XSK group with higher dose,the effect of XSK group with lower dose was equivalent to that of XB group.Hence,XSK granule could enhance the CHF rabbits,heart function,improve their heart endocrine activity,this drug had a reliable effect on CHF.