丹参对体外循环中肺内氧自由基产生的影响

Effect of Radix Salviae Miltiorrhizae on Production of Free Radical Products from Lung during Cardiopulmonary Bypass Operation

３０例心脏瓣膜置换手术患者，随机分为对照组和丹参用药组。于体外循环前及心脏复跳后１０ｍｉｎ、４５ｍｉｎ、２ｈ、６ｈ检测肺循环前（右房）、后（左房）血中过氧化脂质浓度和白细胞数。结果：肺再灌注早期对照组左房血白细胞数低于．右房血而左房血过氧化脂质浓度高于右房血（Ｐ＜０．０１～０．０５），用药组左、右房血白细胞数和过氧化脂质浓度无差异（Ｐ＞０．０５）。表明丹参能显著抑制白细胞肺内聚集，明显减少肺内氧自由基的产生。提示：丹参减少肺内氧自由基产生的作用与其抑制白细胞肺内聚集有关。

Thirty patients of heart valve replacement were randomly divided into two groups, one as Radix Salviae Miltiorrhizae(RSM) treatment group and the other as control group. Blood samples were taken from right atrium(RA) and left atrium (LA) before cardiopulmonary bypass operation(CPB) and 10 min, 45 min, 2 hours, 6 hours after the removal of the aortic cross-clamp to observe the level of peroxidation product and the changes in leucocyte count. The results showed that the number of leucocyte in LA was smaller than that in RA and the amount of peroxidation product in LA was higher than that in RA (P <0.01 ～0.05) during the early phase of the lung reperfusion in control group. There was no significant difference(p > 0.05) in the amount of peroxidation product and the number of leucocyte between LA and RA in RSM treatment group. The results demonstrated that RSM could markedly prevent the lung leucocyte aggregation and reduce the production of lung free radical products. It suggested that the effect of RSM of reducing the production of lung free radical products was related to its effect of preventing the lung leucocyte aggregation.