中药配合脐血输注治疗再生障碍性贫血的临床观察

Clinical Observation on Aplastic Anemia Treated with Chinese Herbal Medicine Combined with Cord Blood Infusion

４８例再生障碍性贫血（再障）分为两组。治疗组３０例采用中药配合脐血输注治疗，对照组１８例采用单纯脐血输注治疗。治疗组与对照组总有效率分别为９３．３％与７２．２％。两组比较有显著性差异（Ｐ＜０．０５）。两组再障患者治疗前后骨髓粒－单系祖细胞（ＣＦＵ－ＧＭ）体外培养结果表明，两组患者治疗后３个月骨髓ＣＦＵ－ＧＭ增高水平接近，治疗后６个月治疗组（１８例）骨髓ＣＦＵ－ＧＭ持续稳定上升，而对照组（１０例）治疗后６个月与治疗后３个月比较有所下降，提示治疗组骨髓造血的恢复比对照组稳定。中药配合脐血输注是中西医综合治疗再障的有效方法。

Forty-eight cases of aplastic anemia (AA) were divided into two groups: the treated group (30 cases) were treated with Chinese herbal medicine and cord blood infusion, the control group (18 cases) were treated with cord blood infusion solely. The total effective rate in the treated group and the control group was 93.3% and 72.2% respectively, the difference between two groups was significant (P<0.05). Cultures of bone marrow granulocyte-macrophage colony forming units (CFU-GM) in vitro were measured also in both groups. Results showed that 3 months after treatment, the elevation of CFU-GM in the two groups were similar to each other, but after 6 months' treatment, level of CFU-GM in treated group elevated persistently and steadily, while in control group, it decreased slightly as compared with level at 3 months' treatment, suggesting the recovery of bone marrow hematopoiesis of treated group was more stable than that of control group. This study indicated that combined treatment of Chinese herbal medicine and cord blood infusion is an effective method in treating AA.