茶多酚预防鹌鹑高脂血症的实验研究

Experimental Study on Tea Polyphenols in Prevention of Hyperlipidemia

用高脂饲料诱发鹌鹑造成高脂血症，同时预防性给予三种剂量茶多酚，并设立空白对照组、模型组及烟酸组，观察茶多酚对鹌鹑高脂血症形成和发展的影响。结果表明：茶多酚抑制鹌鹑血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）水平的升高，茶多酚大剂量组抑制ＴＣ水平升高的作用强于烟酸组，抑制ＴＧ和ＬＤＬ－Ｃ水平升高的作用与烟酸组相仿；茶多酚及烟酸对血清ＨＤＬ－Ｃ水平无明显影响，但两者都能抑制动脉粥样硬化指数（ＴＣ／ＨＤＬ－Ｃ）的升高，且作用相仿。提示茶多酚可望成为一种良好的调节血脂药物。

Hyperlipidemia (HP) was induced in quails by feeding high lipid food. Effect of tea polyphenol (TP) on development of HP was observed by feeding various dosage of TP simultaneously and was compared with that of nicotinic acid (NA). The results showed: (1) TP could prevent the increase of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C).Effect of the group treated with large dose of TP was more significant than that treated with NA (P<0. 05). But no statistically significant difference was observed on the changes of TG and LDL-C between TP and NA treated group.(2) No significant change of HDL-C level was observed in both TP groups and NA group, but both of them could inhibit the elevation of atherogenic index (TC/HDL-C), their effects were similar. It suggested that TP might be a regulator of blood lipid.