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微囊藻毒素MC-LR对Raji细胞中Epstein-Barr病毒早期抗原的诱导 被引量：5

Epstein-Barr Virus Early Antigen Induction in Raji Cells by Microcystin-LR
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摘要 研究微囊藻毒素-LR对EB病毒早期抗原的诱导作用。采用免疫酶法激活Raji细胞中EB病毒早期抗原的表达。微囊藻毒素-LR可以诱导Raji细胞中EB病毒早期抗原的表达,当与丁酸、巴豆油、TPA等促癌物协同作用时,其表达率明显增高。 The effects of microcystin-LR on inducing Epstein-Barr virus early antigen （EBV-EA） are studied, and the expression of EBV-EA is activated by means of immunoenzymatic techniques. It is found that microcystin-LR not only induces the expression percent of EBV-EA but also markedly increases the expression percent of EBV-EA when in cooperation with tumor promoter such as n-butyrate, croton oil and 12-o-tetradecanoyl-phorbol- 13-acetate （TPA）.
作者 柳丽丽 叶树清 钟儒刚 曾毅
机构地区 北京工业大学生命科学与生物工程学院 中国疾病预防控制中心病毒病预防控制所
出处 《武汉科技大学学报》 CAS 2006年第4期422-424,共3页 Journal of Wuhan University of Science and Technology
基金 北京市人才强教基金资助项目(R05351)
关键词 微囊藻毒素 EB病毒 促癌物 microcystin-LR Epstein-Barr virus tumor promoter
分类号 R73 [医药卫生—肿瘤]
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参考文献6

  • 1Batista T,Sousa G D,Suput S,et al.Microcystin-LR Causes the Collapse of Actin Filaments in Primary Human Hepatocytes[J].Aquatic Toxicology,2003,65:85-91.
  • 2殷丽红,屈卫东,朱惠刚.微囊藻毒素致肝癌研究进展[J].国外医学（卫生学分册）,2005,32(3):170-174. 被引量：8
  • 3Fleming L E,Rivero C,Burns J,et al.Blue Green Algal (Cyanobacterial) Toxins,Surface Drinking Water and Liver Cancer in Florida[J].Harmful Algae,2002,(1):157-168.
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  • 5Ito Y.Combined Effect of the Extracts from Croton Tiglium,Luphorbia Lathyris or Euphorbia Tirucalli and n-butyrate on Epstein-Barr Virus Expression in Human Lymphoblastoid P3HR-1 and Raji Cells[J].Cancer Lett,1981,12:175-180.
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二级参考文献52

  • 1王红兵,朱惠刚.我国若干湖泊中蓝藻毒素的遗传毒性研究[J].中国公共卫生学报,1995,14(6):339-341. 被引量：15
  • 2[1]MagalhasesVF, Soares RM, Azevedo SM, et al. Microcystin contamination in fish from the J acarepagua Lagoon (Rio de J aneiro,Brazil): ecological implication and human health risk [ J ]. Toxicol,2001, 39(7): 1077 - 1085.
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共引文献14

同被引文献39

引证文献5

二级引证文献39

武汉科技大学学报
2006年 第4期

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